The Clinical Features and <i>Helicobacter pylori</i> Eradication Therapy in Lymphofollicular Gastritis: A Single Center Experience

An, Hong Ju; Lee, Nam Hun; Kang, Chung; Song, Ho Young; Yang, Joon Seung; Kim, Eun Jeong; Seo, Young Ho

doi:2016.16.4.221

Korean J Helicobacter Up Gastrointest Res > Volume 16(4); 2016 > Article

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2016;16(4):221-225.
DOI: https://doi.org/10.7704/kjhugr.2016.16.4.221 Published online December 10, 2016.

The Clinical Features and Helicobacter pylori Eradication Therapy in Lymphofollicular Gastritis: A Single Center Experience

Hong Ju An, Nam Hun Lee, Chung Kang, Ho Young Song, Joon Seung Yang, Eun Jeong Kim, Young Ho Seo

Division of Gastroenterology, Department of Internal Medicine, Gwangju Veterans Hospital, Gwangju, Korea. nhlee365@naver.com

림프여포성 위염의 임상적 고찰 및 헬리코박터 제균 치료: 단일 병원 경험

안홍주, 이남훈, 강 충, 송호영, 양준승, 김은정, 서영호

광주보훈병원 내과학교실 소화기내과

Received: 23 August 2016 • Accepted: 6 December 2016

Abstract

BACKGROUND/AIMS
Lymphofollicular gastritis (LFG) is defined as antral gastritis with endoscopic findings characterized by a miliary pattern resembling “goose flesh”. We aimed to analyze the clinical features of LFG and the utility of Helicobacter pylori eradication therapy in LFG. MATERIALS AND METHODS: Patients with LFG, regardless of upper gastrointestinal symptoms (7 men, 28 women; age range, 21~67 years), were examined for H. pylori using the CLO test during endoscopy. One specimen was obtained from the greater curvatures of the lower body and the antrum. Clinical features were compared according to H. pylori-positive status. RESULTS: Among 35 patients with LFG, 31 (88.6%) were infected with H. pylori. LFG predominantly affected young women (28/35, 80.0%; mean age, 43.73 years). One case of gastric cancer with H. pylori-positive LFG was found. H. pylori eradication rate in LFG patients was low (3/12, 25.0%). CONCLUSIONS: LFG is closely associated with H. pylori infection and predominantly affects women and young adults. Future studies are needed to determine whether H. pylori eradication reduces the risk of gastric cancer.

Key Words: Lymphofollicular gastritis; Helicobacter pylori; Eradication therapy