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Korean J Helicobacter  Up Gastrointest Res > Volume 17(2); 2017 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2017;17(2):79-82.
DOI: https://doi.org/10.7704/kjhugr.2017.17.2.79    Published online June 10, 2017.
Risk of Bacterial Infection from Proton Pump Inhibitor Use
Sung Soo Kim, Yunju Jo, Seun Ja Park, Jeong Seop Moon, Dong Ho Lee, Jae Jun Kim, Yong Chan Lee
1Department of Internal Medicine, Uijeongbu St. Mary Hospital, The Catholic University of Korea, Uijeongbu, Korea.
2Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
3Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
4Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. moonjs2@unitel.co.kr
5Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
6Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
7Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
프로톤펌프억제제와 감염 위험
김성수, 조윤주1, 박선자2, 문정섭3, 이동호4, 김재준5, 이용찬6, 대한상부위장관ㆍ헬리코박터학회 교육ㆍ윤리위원회
가톨릭대학교 의과대학 의정부성모병원 내과, 을지대학교 의과대학 내과학교실1, 고신대학교 의과대학 내과학교실2, 인제대학교 의과대학 서울백병원 내과학교실3, 서울대학교 의과대학 분당서울대학교병원 내과학교실4, 성균관대학교 의과대학 삼성서울병원 내과학교실5, 연세대학교 의과대학 내과학교실6
Correspondence:  Jeong Seop Moon,
Email: moonjs2@unitel.co.kr
Received: 11 January 2017   • Revised: 6 March 2017   • Accepted: 7 March 2017
Currently, proton pump inhibitors are used in a wide range of patients with gastroesophageal reflux disease, peptic ulcer, and upper gastrointestinal symptoms such as dyspepsia. In addition, the application of proton pump inhibitors for prevention of gastrointestinal complications induced by non-steroidal anti-inflammatory drugs is expected to increase their use in the future. The use of proton pump inhibitors promotes bacterial growth by reducing gastric acid concentration. If the acidity (pH) of the stomach fluid is lower than 4, most pathogens can be sterilized. However, patients who need to use a proton pump inhibitor should maintain a gastric acidity of at least 5 or 6, and can be at risk of infections such as pneumonia and Clostridium difficile infection. Several infectious diseases associated with the use of proton pump inhibitors were reviewed.
Key Words: Clostridium difficile; Pneumonia; Proton pump inhibitors; Small intestinal bacterial overgrowth; Spontaneous bacterial peritonitis

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