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Korean J Helicobacter Up Gastrointest Res > Volume 20(3); 2020 > Article |
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Study | Gastric sample | # of subjects | Country | Microbial diversity | Bacterial compositions | Other findings |
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Sung et al. [46] (2020) | Biopsy | 587 HP +ve patients (295 eradication group, 292 placebo); 102 pairs before and after HP eradication, 100 pairs before and after placebo administration | Hong Kong | ↑HP eradication | ↑Oral bacteria (Peptostreptococcus, Streptococcus, Parvimonas, Prevotella, Rothia) and ↑Granulicatella with emergence and persistence of AG/IM | ↑Acinetobacter Iwoffii, ↑Streptococcus anginosus, ↑Ralstonia, ↓Roseburia, ↓Sphiugomouas with persistent inflammation 1 year after HP eradication; ↑amino acid metabolism, ↑inositol phosphate metabolism, ↓folate biosynthesis, ↓NOD-like receptor signaling in AG/IM |
Gantuya et al. [37] (2020) | Biopsy | 168 (48 GC, 20 normal gastric mucosa, 20 gastritis, 40 AG, 40 IM) | Mongolia | ↓Gastritis, AG, ↑IM, GC | ↑Firmicutes, Lactobacillus, Enterococcus in IM and GC; Carnobacterium, Glutamicibacter, Paeniglutamicibacter, Fusobacterium, Parvimonas were associated with GC regardless of HP infection. | ↑Functional metabolic activity of the Embden-Meyerhof-Parnas pathway and the utilization of sugar in GC |
Ferreira et al. [61] (2018) | Biopsy | Discovery cohort: 81 gastritis, 54 GC; validation cohorts: 15 gastritis, 23 GC | Portugal | ↓GC | ↑Actinobacteria, Firmicutes, Proteobacteria in GC (non-HP); ↓Bacteroidetes, Fusobacteria in GC; ↑Achromobacter, Citrobacter, Lactobacillus, Clostridium, Rhodococcus, Phyllobacterium in GC; ↓Helicobacter, Neisseria in GC | β-diversity indices distinguished GC from gastritis; ↑MDI in IM, GC; ↑membrane transport, carbohydrate metabolism, transcription, xenobiotics biodegradation and metabolism, cellular processes and signaling, metabolism, signal transduction, amino acid metabolism and lipid metabolism in GC; ↑nitrate reductase and nitrite reductase functions in GC. |
Park et al. [44] (2019) | Biopsy | 48HP-veSG, 9HP-ve IM, 23 HP-veGC, 14 HP +ve SG, 12 HP +ve IM, 32 HP +ve GC | Korea | ↓HP +ve SG, HP +ve IM, GC vs. HP -ve SG | ↓Cyanobacteria in HP -ve SG; ↑Rhizobiales in IM | ↑Genes encoding T4SS |
Coker et al. [34] (2018) | Biopsy | Discovery cohort: 21 SG 23 AG, 17 IM, 20 GC; validation cohort: 56 SG, 51 AG, 19 GC | Hong Kong | ↓IM, GCvs. SG | ↑Fusobacteria in GC; ↑Peptostreptococcus, Dialister, Mogibacterium in GC vs. SG, AG, IM; ↓Vogesella, Comamonadaceae and Acinetobacter in GC | β-diversity indices were not different between SG, AG, and IM, but was different between GC and the other groups; ↑strength in microbial interaction networks with disease progression; ↑nucleotide/purine metabolism, carbohydrate digestion and absorption, and peptidoglycan biosynthesis in GC. |
Hsieh et al. [62] (2018) | Biopsy | 9 gastritis, 7 IM, 11 GC | Taiwan | NA | ↑Clostridium, Fusobacterium, Lactobacillus in GC; insignificant findings regarding IM | — |
Sohn et al. [40] (2017) | Biopsy (antrum /body) | 2 HP -ve control, 2 HP -ve cancer, 3 HP +ve control, 5 HP +ve cancer | Korea | ↑HP-cancer vs. HP+cancer | ↑number of non-HP UB and non-HP NB in HP -ve cancer than the others; S. pseudopneumoniae, S. parasanguinis, S. oralis in HP-cancer than the others in the body but not in the antrum | Analysis of microbiota from body mucosa could be beneficial to identify a role of non-HP bacteria in the gastric carcinogenesis. |
Li et al. [39] (2017) | Biopsy | 8 healthy, 9 HP gastritis, 9 IM, 7 GC | Hong Kong | ↓HP gastritis, IM, GC vs. normal | 13 taxa (Nisseria, Fusobacterium, Haemophilus parainfluenzae, etc.) were increased in GC | After eradication ‘normal’ gastric microbiota is established |
Castaño-Rod-ríguez et al. [36] (2017) | Biopsy | 20 FD, 12 GC | Singapore, Malaysia | ↑GC | ↑Lactococcus, Fusobacterium, Bacillus, Staphylococcus, unclassified Pasteurellaceae, Veillonella, Prevotella, Lactobacillus, Fusobacterium, Clostridium, Leptotrichia in GC | Functional predictions showed association with HP serological status but not with disease; ↑pathways of carbohydrate metabolism and carbohydrate digestion and absorption in GC, when HP serology was nested as a subclass; ↑microbial interaction networks in GC vs. FD |
Thorelletal.[63] (2017) | Biopsy | 5 HP-controls, 6 NAG, 9 low-grade corpus AG, 6 extensive corpus AG, 4 corpus IM | Nicaragua | No significant difference | No significant changes in genera abundance between histopathological diagnosis or in relation to the level of molecular atrophy in the tissue | β-diversity (Bray-Curtis index) was not different between histopathological diagnosis |
Parsons et al. [64] (2017) | Biopsy | 20 normal stomach, 22 HP +ve SG, 23 HP +ve AG | UK | ↑AG vs. SG | ↓Tannerella (Escherichia coli/Shigella/Salmonella), Treponema, and Prevotella in AG vs. normal stomach | ↑Microbial co-occurrence networks in AG vs. SG; ↑in several dehydrogenases and ↓glycerate dehydrogenase pathway in AG vs. SG |
Jo et al. [57] (2016) | Biopsy (antrum) | 13 HP -ve control, 19 HP +ve control, 16 HP -ve cancer, 15 HP +ve cancer | Korea | No significant difference between 4 groups | ↑Non-HP NB in GC | β-diversity (unweighted UniFrac) weakly separated control and cancer groups under identical HP infection status |
↑Actinobacteria in GC | ||||||
↑Staphylococcus epidermidis in GC | ||||||
Wang et al. [31] (2016) | Biopsy | 6 gastritis, 6 GC | China | Gastritis=GC (Shannon index) | Nonsignificant enrichment of Lactobacillus, Escherichia, Nitrospirae, Burkholderia, Lachnospiraceae in GC; Nitrospirae present in all GC and absent in gastritis | — |
Eun et al. [35] (2014) | Biopsy | 10 gastritis, 10 IM, 11 GC | Korea | ↑GC vs. gastritis, IM=gastritis | ↓Helicobacteraceae in GC vs. gastritis or IM, in Helicobacter-dominant patients; ↑Streptococcaceae in GC vs. gastritis or IM in HP-dominant patient. | — |
Modified from Rajilic-Stojanovic et al. Aliment Pharmacol Ther 2020;51:582-602. [42]
HP, Helicobacter pylori; +ve, positive; AG, atrophic gastritis; IM, intestinal metaplasia; NOD, nucleotide-binding oligomerization domain; GC, gastric cancer; MDI, microbial dysbiosis index; -ve, negative; SG, superficial gastritis; T4SS, type-IV secretion system; NA, non-applicable; UB, urease-producing bacteria; NB, nitrosating bacteria; S., Streptococcus; FD, patients with functional dyspepsia; NAG, nonatrophic gastritis.
Natural Course of Atrophic Gastritis and Intestinal Metaplasia2020 June;20(2)
Histopathologic Diagnosis of Atrophic Gastritis and Intestinal Metaplasia2020 June;20(2)
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