Molecular Genetic Approach of Gastric MALT Lymphoma

Kim, Myungshin; Kang, Chang Suk

doi:2011.11.3.161

Korean J Helicobacter Up Gastrointest Res > Volume 11(3); 2011 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2011;11(3):161-164.
DOI: https://doi.org/10.7704/kjhugr.2011.11.3.161 Published online December 10, 2011.

Molecular Genetic Approach of Gastric MALT Lymphoma

Myungshin Kim, Chang Suk Kang

¹Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
²Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. cskang@catholic.ac.kr

위 MALT 림프종의 분자유전학적 접근

김명신¹, 강창석²

가톨릭대학교 의과대학 진단검사의학교실¹, 병원병리학교실²

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a common low grade B-cell lymphoma arising from a background of chronic inflammatory disease at a number of mucosal sites. The association between Helicobacter pylori and gastric MALT lymphoma is well known and it appears that H. pylori is critical for lymphomagenesis and also creates a microenvironment favoring the growth of neoplastic B cells. The understanding of MALT lymphoma biology has significantly improved, and at least 4 recurrent translocations t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, t(14;18)/IGH-MALT1 and t(3;14)/IGH-FOXP1 have been implicated in the pathogenesis of MALT lymphoma. Here, we review the recent advances in association of microorganisms with MALT lymphoma and the molecular genetics underlying the lymphoma development.

Key Words: Mucosa-associated lymphoid tissue lymphoma; Chromosomal translocation; Bacteria