<i>Helicobacter pylori</i> and Gastric Microbiota

Oh, Jung Hwan

doi:2016.16.2.59

Korean J Helicobacter Up Gastrointest Res > Volume 16(2); 2016 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2016;16(2):59-67.
DOI: https://doi.org/10.7704/kjhugr.2016.16.2.59 Published online June 10, 2016.

Helicobacter pylori and Gastric Microbiota

Jung Hwan Oh

Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. ojh@catholic.ac.kr

Helicobacter pylori와 위 미생물무리

오정환

가톨릭대학교 의과대학 성바오로병원 내과학교실

Abstract

After completing the human microbiome project, the microbiota has begun to make a mark. Among trillions of microbes in the human microbiome, microbiota in the gastrointestinal tract play significant roles in maintenaning hemostasis of the body. Most research have focused on the gut microbiota. The stomach, which secrets strong acid was regarded as a sterile environment from bacteria; however, the discovery of Helicobacter pylori has changed this paradigm. In this review, we examined the association between H. pylori and gastric microbiota. H. pylori might change the microbiota composition in the stomach as well as the intestine. Probiotics might improve H. pylori associated inflammation in the stomach. In addition, the results of adding probiotics to standard H. pylori therapy are summarized based on recent studies. Microbiota can be a useful tool for preventing or treating human diseases in the near future.

Key Words: Anti-bacterial agents; Helicobacter pylori; Microbiota; Probiotics; Stomach