Gastric Microbiota and Gastric Cancer

Jung, Kyoungwon; Park, Moo In; Kwon, Hye Jung; Kim, Sung Eun

doi:2016.16.2.73

Korean J Helicobacter Up Gastrointest Res > Volume 16(2); 2016 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2016;16(2):73-81.
DOI: https://doi.org/10.7704/kjhugr.2016.16.2.73 Published online June 10, 2016.

Gastric Microbiota and Gastric Cancer

Kyoungwon Jung, Moo In Park, Hye Jung Kwon, Sung Eun Kim

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. mipark@kosinmed.or.kr

위 미생물무리와 위암

정경원, 박무인, 권혜정, 김성은

고신대학교 의과대학 내과학교실

Abstract

The stomach had been recognized as an organ where many bacteria cannot survive due to the presence of gastric acid. However, a number of bacteria have been detected after the discovery of Helicobacter pylori with recent advances in nucleotide sequencing techniques and bioinformatics. These include Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria. Several animal studies suggested that the imbalance of gastric microbiotas could be associated with the development of gastric cancer. Changes in the composition of the gastric microbiota may increase the production of N-nitroso compounds, which is known to be a carcinogen. Further studies on the actual function and proteomics of gastric microbiota could be beneficial for prevention, early diagnosis, and new treatment strategies of gastric cancer.

Key Words: Gastric cancer; Helicobacter pylori; Microbiota