Association of T-antigen of Jamestown Canyon Virus with Early Gastric Cancer

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2010;10(1):27-31.
Published online July 10, 2010.

Jamestown Canyon Virus T-antigen과 조기위암과의 상관관계

손혁수ㆍ전성우ㆍ정민규ㆍ김성국ㆍ김정탁*ㆍ최유진*ㆍ쉬즈광*ㆍ배한익*

경북대학교 의학전문대학원 내과학교실, 경북대학교병원 인체자원은행*

Abstract

Background/Aims
Subclinical infection with Jamestown Canyon (JC) virus occurs in 90% of the population worldwide. Because JC virus enters through tonsillar stromal tissue and persists quiescent in the kidney and lymphoid tissue during latency. However, it may be activated under immunosuppressive conditions, leading to progressive multifocal leucoencephalopathy. In recent years, it has been suggested that the presence of JC virus correlates with various types of human neoplasm, including brain tumours, colorectal cancer, gastric cancer, etc. In this study, we investigated association of T-antigen of activated JC virus with early gastric cancer. Methods: Twenty patients who was diagnosed early gastric cancer underwent endoscopic submucosal dissection. Normal tissue was obtained at the gastric antrum by forceps biopsies. Extracted RNA was converted to cDNA and the PCR amplification and electrophoresis of JC Virus T-antigen was performed. Results: The presence of 300 base-pair T-antigen sequences was shown in 14 of 20 samples (70%) in tumor tissue. In contrast, the presence of 300 base-pair T-antigen sequences was not shown in normal tissue. Conclusions: This study shows that T-antigen of JC virus is significantly associated with early gastric cancer. Further researches on the pathogenesis are warranted. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2010;10:27-31)

Key Words: JC virus, T-antigen, Gastric cancer