The Effect of Proton Pump Inhibitor 'On-demand' Therapy on GERD in Children

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2010;10(1):32-36.
Published online July 10, 2010.

소아 GERD에 대한 프로톤펌프억제제 'On-demand' 치료의 효과

이지혁ㆍ김미진ㆍ최연호

성균관대학교 의과대학 삼성서울병원 소아청소년과학교실

Abstract

Background/Aims
The purpose of this prospective study was to evaluate the effect of proton pump inhibitor (PPI) 'on-demand' therapy on gastro-esophageal reflux disease (GERD) in children. Methods: After 8 week-treatment with lansoprazole in patients with erosive reflux disease (ERD) or non-erosive reflux disease (NERD), 14 ERD and 10 NERD patients who showed partial improvement were treated with 'on-demand' therapy for another 16 weeks. We evaluated symptom score, compliance, and adverse event at week 8 and week 16. Results: In ERD patients, improvement was achieved in 50.0% (7/14) at week 8 and 71.4% (10/14) at week 16. In NERD patients, the rates were 60.0% (6/10) at week 8 and 80.0% (8/10) at week 16. Adverse event was found in one case (4.2%) with NERD, who had lower abdominal pain. Conclusions: PPI was very effective and safe in treatment of children with ERD or NERD. The compliance of medication was good. In patients with partial improvement after 8 weeks' initial treatment, 'on-demand' therapy was very useful as a maintenance therapy, and 'on-demand' therapy for the additional 16 weeks was more effective than 8 weeks' treatment. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2010;10:32-36)

Key Words: GERD, ERD, NERD, PPI, On-demand therapy