| Interleukin-1B (IL-1B) Polymorphisms and Gastric Mucosal Levels of IL-1 |
| 위암 환자에서의 Interleukin-1B 유전자 다형성과 위점막의 IL-1β 농도와의 관계 |
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김경진·장영운·손성동·장재영·남기덕·김남훈·이상길·주광로·동석호·김효종·김병호·이정일·장 린 |
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경희대학교 의과대학 소화기내과학교실 |
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| Abstract |
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Background/Aims: Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1β and an increased risk of developing GC in a Korean population. Methods: Polymorphisms of IL-1A-889, IL-1B-31, -511, and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-1β cytokine was measured using an ELISA. Results: The frequencies of IL-1A, IL-1B-511, IL-1B-31, and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR 2.2; 95% CI, 1.1∼4.3) compared with controls. As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1β levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C. Conclusions: Thus the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1β production contributed to the development of intestinal-type GC in this Korean population. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2004;4:30-39) |
| Key Words:
Gastric cancer, Interleukin-1B polymorphisms, IL-1β mucosal level |
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