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Korean J Helicobacter  Up Gastrointest Res > Volume 12(1); 2012 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2012;12(1):27-33.
DOI: https://doi.org/10.7704/kjhugr.2012.12.1.27    Published online March 10, 2012.
The Determining Factors for Treatment Modality and the Results of Gastric Maginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue: Single Center Experience
Dae Young Cheung, Jung Ho Kim, Tae Ho Kim, Hyung Keun Kim, Sung Soo Kim, Jin Il Kim, Soo Heon Park, Jae Kwang Kim
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. jikim@catholic.ac.kr
위 변연부 B-세포 림프종의 치료방침 결정에 대한 요인과 그 결과 분석: 단일기관 경험
정대영, 김정호, 김태호, 김형근, 김성수, 김진일, 박수헌, 김재광
가톨릭대학교 의과대학 내과학교실
Though the gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) of Lugano stage IE and IIE1 can often be turned into complete remission with antibiotics treatment, other treatment modalities including surgery and chemotherapy are employed in some cases. The purpose of this study was to evaluate the determining factors for treatment modality and the result of the different treatment modalities. MATERIALS AND METHODS: We reviewed the medical records of patients diagnosed with gastric MALT lymphoma in Yeoido St. Mary's Hospital from March 2002 to Feb 2010. RESULTS: All 16 patients were diagnosed with gastric MALT lymphoma at stage IE and IIE1. Three patients received chemotherapy with cyclophosphamide, adriamycin, vincristine, prednisolone (CHOP) regimen, 3 patients underwent surgery and the other 10 patients received antibiotics only. All patients achieved complete remission within 5.1+/-5.1 months and remained stable for 34.8+/-17.6 months. There were no difference in oncologic outcome between the treatment modalities. The positivity of Helicobacter pylori (H. pylori) infection and the gastroenterology specialty of physician in charge lead to antibiotics treatment rather than other modalities (P<0.05). CONCLUSIONS: The H. pylori infection status and the specialty of the physician in charge were the meaningful determining factors for treatment modalities.
Key Words: Stomach; Lymphoma, B cell, Marginal zone; Anti-Bacterial agents; Antineoplastic agents; Gastrectomy

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