| Change in the Prevalences and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia in Korea: Multicenter Clinical Trials |
Young Jae Hwang 
, Nayoung Kim
, Sung Eun Kim
, Gwang Ho Baik
, Ju Yup Lee
, Kyung Sik Park
, Young Eun Joo
, Dae Seong Myung
, Hyeon Ju Kim
, Hyun Joo Song
, Heung Up Kim
, Kwangwoo Nam
, Jeong Eun Shin
, Hyun Jin Kim
, Gwang Ha Kim
, Jongchan Lee
, Seon Hee Lim
, Geom Seog Seo
, Suck Chei Choi
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1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. nayoungkim49@empas.com
2Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
3Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Korea.
4Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
5Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
6Department of Family Medicine, Jeju National University School of Medicine, Jeju, Korea.
7Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
8Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
9Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
10Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
11Department of Internal Medicine, Seoul National University Healthcare System Gangnam Center and Healthcare Research Institute, Seoul, Korea.
12Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. |
| 위축성 위염과 장상피화생의 유병률 변화 및 위험인자의 변화: 다기관 연구 비교 |
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황영재1, 김나영1, 김성은2, 백광호3, 이주엽4, 박경식4, 주영은5, 명대성5, 김현주6, 송현주7, 김흥업7, 남광우8, 신정은8, 김현진9, 김광하10, 이종찬1, 임선희11, 서검석12, 최석채12 |
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분당서울대학교병원 내과1, 고신대학교 의과대학 내과학교실2, 한림대학교 의과대학 내과학교실3, 계명대학교 의과대학 내과학교실4, 전남대학교 의과대학 내과학교실5, 제주대학교 의학전문대학원 가정의학교실6, 내과학교실7, 단국대학교 의과대학 내과학교실8, 경상대학교 의과대학 내과학교실, 건강과학연구원9, 부산대학교 의과대학 내과학교실10, 서울대학교병원 헬스케어시스템 강남센터 내과 및 헬스케어연구소11, 원광대학교 의과대학 내과학교실12 |
Correspondence:
Nayoung Kim, Tel: +82-31-787-7008, Fax: +82-31-787-4051,
Email: nayoungkim49@empas.com
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Received: 23 July 2018 • Revised: 4 September 2018 • Accepted: 6 September 2018 |
| Abstract |
BACKGROUND/AIMS
The aim of this study was to analyze the trend of the prevalences of atrophic gastritis (AG) and intestinal metaplasia (IM) from 2011 to 2016~2017 in Korea. And, the risk factors of AG and IM were compared between 2011 and 2016~2017. MATERIALS AND METHODS: A total of 4,023 subjects in 2011 and 2,506 subjects in 2016~2017 were enrolled. AG and IM were diagnosed on the basis of endoscopic findings. Multivariate analysis was performed for risk factors of AG and IM. Seventeen factors were analyzed. RESULTS: The seroprevalence of Helicobacter pylori decreased from 2011 (59.8%; 2,407/4,023) to 2016~2017 (51.6%; 1,293/2,506; P < 0.001). The prevalence of AG decreased from 2011 to 2016~2017 (P=0.018), but that of IM increased (P < 0.001). The risk factors of AG in 2011 were male sex, old age, H. pylori immuoglobulin G (IgG) positivity, family history of gastric cancer (GC), and high-salt diet. For IM in 2011, the risk factors were male sex, old age, H. pylori IgG positivity, and family history of GC. Risk factors of AG in 2016~2017 were old age, H. pylori IgG positivity, and country of residence. For IM in 2016~2017, the risk factors were male sex, old age, family history of GC, high fasting glucose level (≥126 mg/dL), H. pylori IgG positivity, and low income level. CONCLUSIONS: The difference in prevalence trends of AG and IM between 2016~2017 and 2011 could be the result of the different risk factors of AG and IM, such as decreased prevalence of H. pylori infection. |
| Key Words:
Atrophic gastritis; Helicobacter pylori; Metaplasia; Prevalence; Risk factors |
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