The Relationship between <i>Helicobacter pylori </i>Infection and High-sensitivity C-reactive Protein

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2008;8(2):91-96.
Published online December 10, 2008.

The Relationship between Helicobacter pylori Infection and High-sensitivity C-reactive Protein

Helicobacter pylori 감염과 High-sensitivity C-reactive Protein (hs-CRP)과의 관계

박태영ㆍ김정욱ㆍ김재규

중앙대학교 의과대학 소화기내과학교실

Abstract

Background/Aims
Since chronic infections are possible risk factor of cardiovascular disease were suggested, many researches about the relationship between inflammatory biomarker and atherosclerosis are progressing. The relationship between Helicobacter pylori infection and high-sensitivity C-reactive protein (hs-CRP), total cholelsterol, triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) was analyzed. Methods: Forty-eight patients diagnosed with gastric ulcer, duodenal ulcer, gastritis with H. pylori infection on esophagogastroduodenoscopy were enrolled. We analyzed 23 patients (M=17, F=6) followed up hs-CRP. Results: hs-CRP of 23 patients was decreased from 0.70±0.86 mg/L to 0.64±1.13 mg/L after H. pylori eradication, but there was no statistical significance. hs-CRP of male 17 patients was increased from 0.61±0.52 mg/L to 0.77±1.30 mg/L and hs-CRP of female 6 patients was was decreased from 0.92 ± 1.50 mg/L to 0.31±0.37 mg/L after H. pylori eradication, but there was no statistical significance. There was no statistical significance in total cholelsterol, TG, HDL and LDL. Conclusions: H. pylori eradication may not have effect on serum hs-CRP, total cholelsterol, TG, HDL and LDL. This study suggests it needs large prospective study to confirm the relationship between H. pylori infection and hs-CRP. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2008;8:91-96)

Key Words: Helicobacter pylori, High-sensitivity C-reactive protein, Atherosclerosis