Korean J Helicobacter  Up Gastrointest Res Search


The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2006;6(2):129-137.
Published online December 9, 2006.
The Effect of Blood Interleukin-4 Production and Interleukin-4 Genetic Polymorphism on Helicobacter pylori Eradication
혈중 Interleukin-4 분비와 Interleukin-4 유전자 다형성이 Helicobacter pylori 제균에 미치는 영향
권정현·정인식·박호성·서정필 남관우·백창렬·박재명·조유경·이인석·김상우·최명규
가톨릭대학교 의과대학 내과학교실
Background/Aims: It has been suggested that the Th1 immune system is involved in the inflammatory reaction Helicobacter pylori (H. pylori), while the Th2 immune system in the eradication of H. pylori. This research aims to find out the effects of interleukin-4 (IL-4) production levels and genetic polymorphism of IL-4 and IL-4Rα in the eradication of H. pylori. Methods: 103 dyspeptic patients were divided into two groups according to H. pylori infection. IL-4 productions, stimulated H. pylori and polymorphism of interleulcin-4 (IL-4), IL-4Rα gene were measured in the whole blood specimen. The former measurement was repeated after the eradication in H. pylori positive group. Results: There was no difference in the IL-4 production and IL-4 polymorphism according to H. pylori status. But a significant increased IL-4 production was detected in the eradicated group compared to non-eradicated group before eradication. After eradication, there was no difference of IL-4 production in the both groups although there was a trend toward increased levels in eradicated group. Conclusions: Blood IL-4 production, a major cytokine of the Th2 immune system, was increased in the H. pylori eradicated group before the eradication. This suggests that increased blood IL-4 production before eradication may contribute to the successful eradication of H. pylori. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2006;6:129-137)
Key Words: Helicobacter pylori, interleukin-4, Polymorphism

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