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Korean J Helicobacter  Up Gastrointest Res > Volume 18(1); 2018 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2018;18(1):30-37.
DOI: https://doi.org/10.7704/kjhugr.2018.18.1.30    Published online March 10, 2018.
Helicobacter pylori Eradication in Patients with an Iatrogenic Ulcer after Endoscopic Resection and Peptic Ulcer
Seol So, Ji Yong Ahn, Hee Kyong Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon Yong Jung
Department of Gastroenterology, Asan Medical Center, Asan Digestive Disease Research Institute, University of Ulsan College of Medicine, Seoul, Korea. ji110@hanmail.net
Correspondence:  Ji Yong Ahn, Tel: +82-2-3010-5667, Fax: +82-2-476-0824, 
Email: ji110@hanmail.net
Received: 6 October 2017   • Revised: 9 December 2017   • Accepted: 10 December 2017
We aimed to compare the outcomes and timing of Helicobacter pylori eradication in patients with iatrogenic and peptic ulcers. MATERIALS AND METHODS: This was a retrospective study of 183 patients treated between 2012 and 2015 with 7-day standard triple therapy after endoscopic resection (ER). The patients were enrolled as the iatrogenic ulcer group and assigned to an early treatment group (n=139, H. pylori eradication initiated 2 days after ER) and a late treatment group (n=44, 8 weeks after ER). During the same period, 152 patients with peptic ulcer were assigned to the peptic ulcer group. RESULTS: Successful H. pylori eradication was achieved in 141 patients (77.0%) in the iatrogenic ulcer group and 114 (75.0%) in the peptic ulcer group (P=0.661). Among the ER patients, the eradication rate was 79.9% (n=111) in the early treatment group and 68.2% (n=30) in the late treatment group (P=0.109). The adverse event rate was significantly higher in the peptic ulcer group than in the iatrogenic ulcer group (13.8% vs. 4.9%, P=0.005). Compliance and adverse events did not significantly differ between the early and late treatment groups. CONCLUSIONS: In iatrogenic ulcer, H. pylori eradication can be performed with a relatively lower adverse event rate, regardless of treatment timing, than that in peptic ulcer.
Key Words: Endoscopic mucosal resection; Endoscopic submucosal dissection; Helicobacter pylori; Peptic ulcer

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