| Delta 13C-Urea Breath Test Value is a Useful Indicator for Helicobacter pylori Eradication in Patients with Functional Dyspepsia |
| 기능성 소화불량증 환자에서 Helicobacter pylori 제균 지표로서의 13C-요소 호기 검사치의 유용성 |
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장영운·민선기·이병욱·김경진·정용희·한요셉·이주희*·동석호·김효종·김병호·이정일·장 린 |
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경희대학교 의과대학 소화기 내과학교실, *병리학교실 |
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| Abstract |
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Background/Aims: We tried to investigate a useful indicator of H. pylori eradication in patients with functional dyspepsia by determining the optimal cutoff value of 13C-urea breath test(UBT). Methods: Dyspepsia was scored, and 13C-UBT was performed in 100 dyspeptic patients. After the stomach was endoscopically sprayed with phenol red, biopsy specimens were taken from the antrum, body, and cardia for the assessment of H. pylori density, and activity (neutrophil infiltration) and degree(lymphocyte infiltration) of gastritis. Results: Correlation between delta 13C-UBT and dyspepsia score was not found. Delta 13C-UBT significantly correlated with H. pylori density score in the total stomach (r=0.53, P＜0.0001), neutrophil(r=0.34, P=0.0005) and lymphocyte score(r=0.69, P＜0.0001). Twenty-six subjects of the total 100 subjects had neutrophil score ≥4, lymphocyte score ≥4, and H. pylori score ≥4. Their upper 95% confidence interval of mean was 58.2‰, which reflects moderate to marked acute and chronic gastritis, and dense H. pylori colonization. Conclusions: 13C-UBT is a reliable semi-quantitative test to assess H. pylori density and the activity and degree of gastritis. We propose that H. pylori eradication therapy may be beneficial for patients with functional dyspepsia with a delta 13C-UBT of ＞58.2‰. (Korean J Helicobacter Res Prac 2003;3:25-31) |
| Key Words:
Functional dyspepsia, Helicobacter pylori, Delta 13C-UBT |
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