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Korean J Helicobacter  Up Gastrointest Res > Volume 11(1); 2011 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2011;11(1):7-12.
DOI: https://doi.org/10.7704/kjhugr.2011.11.1.7    Published online June 10, 2011.
Helicobacter pylori Virulence Factors and Host Factors
Bong Ku Kang, Byung Wook Kim
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, School of Medicine, Incheon, Korea. gastro@catholic.ac.kr
Helicobacter pylori의 독성인자와 숙주인자
강봉구, 김병욱
가톨릭대학교 의과대학 인천성모병원 소화기내과학교실
Abstract
Helicobacter pylori (H. pylori) is one of the most common human infection world-wide. However, only a limited proportion of the infected population developed gastrointestinal diseases such as peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. These various outcomes of H. pylori infection may result from bacterial virulence factors, host factors such as genetic diversities, and environmental influences. Bacterial factors such as cagA PAI, vacA, adhesin and outer membrane proteins, and peptidoglycans are known to be associated with specific gastrointestinal diseases such gastric adenocarcinoma. Various cytokines including interleukin (IL)-1beta, IL-10, and tumor necrosis factor-alpha, and host immune reaction to the bacteria are closely related to specific diseases such as gastric adenocarcinoma and duodenal ulcer. In this article, we reviewed each factors and their relevance to the disease outcome.
Key Words: Helicobacter pylori; Virulence factors


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