Eradication Therapy for Pediatric <i>Helicobacter pylori</i> Infection

Seo, Ji Hyun; Youn, Hee Shang

doi:2017.17.1.16

Korean J Helicobacter Up Gastrointest Res > Volume 17(1); 2017 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2017;17(1):16-19.
DOI: https://doi.org/10.7704/kjhugr.2017.17.1.16 Published online March 10, 2017.

Eradication Therapy for Pediatric Helicobacter pylori Infection

Ji Hyun Seo, Hee Shang Youn

¹Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea. hsyoun@gnu.ac.kr
²Department of Pediatrics, Gyeongsang Institute of Health Science, Jinju, Korea.

소아 헬리코박터 제균 치료

서지현^1,2, 윤희상^1,2

경상대학교 의학전문대학원 소아청소년과학교실¹, 경상대학교 건강과학연구원²

Received: 28 December 2016 • Revised: 22 February 2017 • Accepted: 23 February 2017

Abstract

In children, Helicobacter pylori infection causes gastritis, peptic ulcer, and extraintestinal manifestations such as refractory iron deficiency anemia, failure to thrive, and chronic idiopathic thrombocytopenia. The outcomes of recommendations for H. pylori eradication therapy in children are not comparable with the eradication rates of those in adults because of the low level of evidence, including randomized placebo-controlled treatment trials. In South Korea, no standard guideline for the management of children with H. pylori infection has been established yet. Herein, we reviewed the indications for and various modalities of eradication therapy in children with H. pylori infection in accordance with a review of published articles. H. pylori-associated peptic ulcer is the only one indication for eradication therapy. A proton pump inhibitor based on a combination of two antibiotics has been considered as the standard eradication therapy in children, but no consensus has been reached regarding the modality of eradication therapy in children.

Key Words: Helicobacter pylori; Child; Therapeutics