Homogenous Subepithelial Esophageal Lesion

Article information

Korean J Helicobacter Up Gastrointest Res. 2023;23(1):73-75

Publication date (electronic) : 2023 March 9

doi : https://doi.org/10.7704/kjhugr.2023.0004

Jin Ook Jang¹, Su Jin Kim^,1,2, Cheol Woong Choi^1,2

¹Division of Gastroenterology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea

²Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea

Corresponding author: Su Jin Kim Department of Internal Medicine, Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Korea Tel: +82-55-360-1535, Fax: +82-55-360-1536, E-mail: endoksj@gmail.com

Received 2023 January 10; Revised 2023 January 29; Accepted 2023 February 5.

Question: A 54-year-old woman was referred to our tertiary center for further evaluation of an esophageal subepithelial tumor (SET) that had been incidentally found during screening endoscopy. The tumor was located in the mid-esophagus and was covered by normal esophageal mucosa (Fig. 1A). According to the patient’s history, the esophageal SET was initially detected at another local medical center 2 years ago. The center may have planned a patient follow-up according to the current practice guidelines, which state that small esophageal SET can be managed by periodic surveillance endoscopy [1]. However, the patient visited another local medical center that considered the SET as a newly discovered lesion and referred her to our center. The size of the esophageal SET increased slightly on endoscopic image. EUS revealed a homogenous hypoechoic lesion measuring 1.0×0.5 cm in the third layer of the esophagus (Fig. 1B).

Fig. 1.

(A) Endoscopic image showing an incidentally detected midesophageal subepithelial tumor covered with normal mucosa. (B) Endoscopic ultrasonographic image showing a homogenous hypoechoic lesion measuring 1.0×0.5 cm in the third layer of the esophagus.

What is the most likely diagnosis?

Answer: We performed an underwater endoscopic mucosal resection (UW-EMR). A 15-mm polypectomy snare (Endo-Flex GmbH, Voerde, Germany) was introduced through a two-channel endoscope (GIF-2TQ260M; Olympus, Tokyo, Japan) that enables the insertion of a snare through an endoscopic channel while maintaining water infusion to completely immerse the tumor. The table was tilted by approximately 15° to prevent aspiration during the procedure. En-bloc resection was achieved. The operative time was 4 minutes. There was no sign of esophageal perforation or residual lesion. The resection margin was negative for tumor cells and lymphovascular invasion. The histological diagnosis revealed esophageal adenoid cystic carcinoma (EACC) of the cribriform type (Fig. 2). Abdominal and chest CT revealed no evidence of lymph node metastasis.

Fig. 2.

(A) Microscopic image of the resected tissue showing the cribriform structure of the tumor cells (H&E stain, ×40). (B) Image showing appearance of the tumor cells using the p63 stain (×200). (C) Image showing appearance of the tumor cells using the S100 stain (×200). (D) Image showing appearance of tumor cells using the cytokeratin 7 (CK7) stain (×200).

The patient wanted an early follow-up, although the risk of lymph node metastasis in early EACC is not well known. Hence, periodic surveillance using endoscopy and chest CT was planned. Endoscopic biopsy from the resected site 3 months after the procedure revealed no residual tumor. Although the patient might have a good prognosis during follow-up, meticulous follow-up plan is still needed.

Adenoid cystic carcinoma is a malignant tumor that most frequently occurs in salivary glands. EACC is rare and accounts for only 0.1% of all esophageal malignancies [2,3]. Dysphagia is the most common symptom. Often, metastases are detected during diagnosis [2]. Endoscopic findings of early stage EACC include small SETs covered with normal mucosa that makes early diagnosis difficult. Previous reports on early stage EACC demonstrated no esophageal symptoms [2,3]. Hence, EUS can be helpful in distinguishing early stage EACC from benign tumors such as leiomyoma.

The treatment of choice for EACC is radical resection with regional lymph node dissection [4]. Histologically, adenoid cystic carcinoma shows three different cellular patterns: cribriform, tubular, and solid [5]. The solid pattern is associated with poorer prognosis than the other two patterns. Moreover, lymph node metastasis and vascular invasion, are associated with poor prognosis [5].

The association of lymph node metastasis with EACC invasion depth is not well known. A recent study reported that lymph node metastasis was found in only 4% of patients (1/25) with EACC who had submucosal or mucosal invasion [4]. In two cases, submucosal invasive EACC was treated by endoscopic resections including endoscopic enucleation and endoscopic submucosal dissection with a good prognosis without additional treatment [2,3,5].

Recently, UW-EMR for esophageal SET in the third layer was introduced as an effective and safe treatment modality with reduced procedure time and complication risk [6]. Therefore, we performed UW-EMR and achieved a complete en-bloc resection.