| Transcriptional Silencing of the Ena/VASP-like Protein (EVL) by Promoter Hypermethylation in Gastric Cancer: Pilot Study |
| 위암에서 Ena/VASP-like Protein (EVL) 유전자 촉진자 과메틸화의 빈도와 의의: 예비 연구 |
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민병훈*ㆍ김영호*ㆍ권영주*ㆍ김현경†ㆍ이준행*ㆍ장동경*ㆍ손희정*ㆍ이풍렬*ㆍ이종철*ㆍ김재준* |
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성균관대학교 의과대학 삼성서울병원 소화기내과*, 대원외국어고등학교† |
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| Abstract |
Background/Aims
The role of Ena/VASP-like protein (EVL) in gastric cancer carcinogenesis is not clear. Therefore, we aimed to evaluate the role of EVL gene promoter hypermethylation in gastric carcinogenesis. Methods: Twenty gastric cancer tissues, 20 non-tumor tissues around cancers, 10 non-tumor stomach tissues of non-cancer patients were analyzed for EVL promoter methylation using methylation-specific PCR. Clinicopathologic characteristics of gastric cancers were compared according to the EVL promoter methylation status. Results: EVL promoter methylation was observed in 80.0%, 20.0%, and 70.0% in gastric cancer tissues, non-tumor tissues around cancers, and non-tumor tissues of non-cancer patients. No significant difference in clinicopathologic characteristics was observed between unmethylated and methylated group in gastric cancer patients. Conclusions: These results suggested that EVL gene promoter hypermethylation may play a role in gastric carcinogenesis as the frequency of methylation in cancer tissues was higher than that of non-tumor tissues around cancers (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2008;8:38-42) |
| Key Words:
EVL gene, Promoter hypermethylation, Gastric cancer |
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