<em>Helicobacter pylori</em>-Negative Low Grade Gastric MALT Lymphoma

Review

대한Helicobacter 연구학회지 2003;3(2):89-95.
Published online November 30, 2003.

Helicobacter pylori-Negative Low Grade Gastric MALT Lymphoma

Helicobacter pylori 감염이 없는 저위도 점막연관림프조직형 위림 프종

이선영·이준행·김재준

성균관대학교 의과대학 내과

Abstract

Helicobacter pylori-negative MALT lymphoma is a rare disease compared to H. pylori-positive MALT lymphoma which is treated by H. pylori eradication. Since no single diagnostic method can confirm H. pylori-negative MALT lymphoma, clinician must be very careful in diagnosis. Only combination of several diagnostic methods such as H. pylori IgG antibody, endoscopic biopsy, and urease breath test are considered to be available in confirming the negativity of H. pylori. Although the pathogenesis of H. pylori-negative MALT lymphoma is not yet clear, micro-organism other than H. pylori, t(11;18)(q21;q21), API2-MALT1 chimera gene, autoimmune associated gastritis, preexisting H. pylori infection are considered as possible causes. In the aspect of treatment, it is still a therapeutic challenge. Surgery, chemotherapy, and radiotherapy are usually performed as a first line therapy in clinical fields. However, some clinicians recommend H. pylori eradication before turning to oncologic or surgical modalities because it is simple, inexpensive, harmless, and may be worthwhile. Further data through a big scale study are necessary to define the treatment modality of this entity. (Korean J Helicobacter Res Prac 2003;3:89-95)

Key Words: Helicobacter pylori-negative MALT lymphoma, t(11; 18)(q21; q21), API2-MALT1 chimera gene, Helicobacter pylori eradication