Annual Eradication Rates of <i>Helicobacter pylori</i> Infection over 9 Years in Incheon

Kim, Boo Gyoung; Kim, Joon Sung; Kim, Byung Wook; Ji, Jeong Seon; Choi, Hwang; Park, Sung Min

doi:2015.15.2.103

Korean J Helicobacter Up Gastrointest Res > Volume 15(2); 2015 > Article

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2015;15(2):103-107.
DOI: https://doi.org/10.7704/kjhugr.2015.15.2.103 Published online June 10, 2015.

Annual Eradication Rates of Helicobacter pylori Infection over 9 Years in Incheon

Boo Gyoung Kim, Joon Sung Kim, Byung Wook Kim, Jeong Seon Ji, Hwang Choi, Sung Min Park

Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea. kijoons@catholic.ac.kr

인천지역에서 9년간 헬리코박터 제균율의 연도별 변화

김부경, 김준성, 김병욱, 지정선, 최 황, 박성민

가톨릭대학교 의과대학 인천성모병원 내과학교실 소화기내과

Abstract

BACKGROUND/AIMS
Failure of Helicobacter pylori eradication has increased over the past decade and is related to increased antibiotic resistance. The aim of this study was to estimate the eradication rates of H. pylori infection over the past 9 years in a single center. MATERIALS AND METHODS: From 2004 to 2013, a total of 5,715 patients were diagnosed with H. pylori infection and were prescribed first line triple regimens. 2,482 patients underwent tests for assessment of eradication by 13C-urea breath test, rapid urease test or histopathological examinations. RESULTS: The overall eradication rate of first line triple regimen was 80.4% and continually decreased during the study period (P=0.011). Among the triple regimens, the eradication rate of two-week and one-week regimens were 90.1% and 79.3%, each. The two-week regimen was superior to the one-week regimen (P=0.000). The overall eradication rates of second line quadruple regimen was 91.4% and there was no significant decrease in the annual eradication rates (P=0.708). The overall eradication rates of both first line and second line therapy were 81.9% and decreased gradually during the study period (P=0.011). Multivariate analysis revealed sex, age, type of proton pump inhibitor, and duration of eradication to be associated with eradication failure. CONCLUSIONS: The eradication rates of first line triple regimen has decreased gradually; however, the eradication rates of second line regimen remains unchanged. Triple regimens of two-weeks seem to be better than one.

Key Words: Helicobacter pylori; Disease eradication